Middletown NY Business Directory Welcome to the Middletown NY Business Directory! Whether you are looking for the best place to eat for dinner on a Friday night, looking for a hotel to spend the night or are looking for a local Middletown New York service provider you have come to the right place! A little about Middletown NY. Middletown is a city in Orange County, New York, United States. It lies in New York’s beatiful Hudson Valley region, near the Wallkill River and the foothills of the Shawangunk Mountains. Middletown is situated between Port Jervis and Newburgh, New York. The city’s population was 25,388 at the 2000 census and 28,086 as of the 2010 census. The zip codes are 10940 and 10941. Local web sites. http://www.middletown-ny.com http://www.thrall.org http://www.owrhs.org